Common questions about an aching joint

Sources

1. A EULAR task force of 18 rheumatologists, 3 health professionals, 2 patients and a methodologist defined which joint symptoms, in the absence of any visible swelling, should make a clinician suspect that inflammatory arthritis is coming. Seven parameters survived: symptom duration under one year, symptoms in the knuckle (metacarpophalangeal) joints, morning stiffness lasting 60 minutes or more, symptoms worst in the early morning, a first-degree relative with rheumatoid arthritis, difficulty making a fist, and a positive squeeze test of the knuckles. The combination identified at-risk patients with an area under the ROC curve of 0.92 (95% CI 0.87-0.96).

   van Steenbergen HW, Aletaha D, Beaart-van de Voorde LJJ, et al. — EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis.. Annals of the Rheumatic Diseases, 2017. DOI: 10.1136/annrheumdis-2016-209846.

2. In a matched case-control study of 40 early rheumatoid arthritis patients followed for 36 months, those who started DMARD therapy at a median disease duration of 3 months improved significantly more than those who started at 12 months. At study end the DAS28 had improved by 2.8 (SD 1.5) in the very-early group versus 1.7 (SD 1.2) in the late-early group, and radiographic joint destruction by Larsen score progressed significantly more slowly in the very-early group.

   Nell VPK, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS — Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis.. Rheumatology (Oxford), 2004. DOI: 10.1093/rheumatology/keh199.

3. A Cochrane overview of 21 systematic reviews (381 studies, 37,143 participants) covering rheumatoid arthritis, osteoarthritis, fibromyalgia, low back pain, neck disorder and other chronic pain conditions concluded that physical activity and exercise are interventions with few adverse events that may improve pain severity and physical function - but that the quality of the evidence is low, effects on pain were inconsistent across reviews, and physical function improved significantly in 14 reviews with only small-to-moderate effect sizes. The commonest reported adverse event was increased muscle soreness that settled within weeks.

   Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH — Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.. Cochrane Database of Systematic Reviews, 2017. DOI: 10.1002/14651858.CD011279.pub3.

4. OARSI's 2019 guideline is the only major osteoarthritis guideline that grades treatments separately for people with disease in MULTIPLE joints. Its Core Treatments for polyarticular OA are arthritis education and structured land-based exercise. Critically, intra-articular corticosteroid and intra-articular hyaluronic acid were Level 1B/2 options for knee OA only and were NOT recommended for hip or polyarticular OA; oral NSAIDs were not recommended at all for people with cardiovascular comorbidity or frailty; and paracetamol/acetaminophen was conditionally not recommended.

   Bannuru RR, Osani MC, Vaysbrot EE, et al. — OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.. Osteoarthritis and Cartilage, 2019. DOI: 10.1016/j.joca.2019.06.011.

5. In a structured review of 14 studies covering 6,242 patients with an acutely painful swollen joint (653 with confirmed septic arthritis), no single symptom rules the diagnosis in or out: joint pain was present in 85%, a history of joint swelling in 78%, and fever in only 57%. The most powerful bedside data came from aspirating the joint - the summary likelihood ratio rose with the synovial fluid white cell count, from 0.32 below 25,000/microL to 2.9 at 25,000 or more, 7.7 above 50,000 and 28.0 above 100,000.

   Margaretten ME, Kohlwes J, Moore D, Bent S — Does this adult patient have septic arthritis?. JAMA, 2007. DOI: 10.1001/jama.297.13.1478.